An impressively realistic and nuanced chronicle of a 27-year-old cancer patient enclosed in a somewhat Hollywoodized wrapping which includes the goofy (albeit warm) comic-relief friend and the customary (albeit sweet) romantic ending. Joseph Gordon-Levitt excels in the lead; he plays Adam with a sensible level of understatement, not falling for the temptation of frequent and loud emotional outbursts. It is Gordon-Levitt's performance which gives the film the authenticity to balance its otherwise lightweight comedy and predictable structure. I have no doubt that Joseph Gordon-Levitt and Anna Kendrick could make a cute couple, but their romance here is too plot-driven and convenient to befit the film's otherwise intelligent handling of a serious subject matter that most people will be able to identify with in one way or another. The ever-charming Seth Rogen gives us another hour-and-a-half of his now familiar on-screen persona. And considering the fact that 50/50 evidently is loosely based on writer Will Reiser's own battle against cancer, accompanied by real-life friend Rogen, I suppose we must now conclude that Rogen's just being himself in front of the camera. I'm excited to see how long his 15 minutes will last.